During the early 1970s Ned Smyth worked on projects with artist Gordon Matta-Clark and exhibited at 112 Greene Street (1974, 1975), an alternative exhibition space located in New York City. At that time, the New York art world was on the verge of expanding the traditional boundaries of art making, and 112 was a principal force.
Beginning in 2011, Smyth curated a series of historical exhibitions and performances for Salomon Contemporary, titled American Responses. The first of these exhibitions, 112 Greene Street: A Nexus of Ideas in the Early 70s featured artists Alice Aycock, Bill Beckley, Louise Bourgeois, Chris Burden, Mary Heilmann, Joan Jonas, Dickie Landry, Dennis Oppenheim, Susan Rothenberg, Carolee Schneemann, Ned Smyth, George Trakas, and Jackie Winsor. The exhibition illuminated the breadth of work that was being explored at a time pivotal to the direction of American contemporary art. The show ran concurrently with 112 Greene Street: The Early Years (1970-1974), curated by Jessamyn Fiore at David Zwirner Gallery.
Smyth then curated solo exhibitions of work from the 1970s by Kim MacConnell, Ned Smyth, Dickie Landry, Tina Girouard, and Suzanne Harris. In conjunction, Smyth produced a solo Dicky Landry concert at the Guggenheim Museum in March 2011.